医師・医学博士

日本脳神経外科学会認定専門医

日本がん治療認定医機構認定医

日本脳卒中学会認定専門医

大阪国際がんセンター 脳神経外科部長

木 下   学

 
 

脳腫瘍は治療成績の向上が未だに達成されておらず、予後不良な疾患として数多くの患者さんを苦しめています。私は現在、少しでも脳腫瘍の診断・治療を向上させるべく、大阪国際がんセンターならびに大阪大学脳神経外科で治療・研究にあたっております。

特に、悪性脳腫瘍の放射線学的な画像化技術の向上、画像誘導下手術技術の開発、中枢神経系悪性リンパ腫の病態解析、間脳下垂体腫瘍を含む頭蓋底腫瘍の外科的治療と病態解析を中心的な臨床・研究テーマとしています。

脳腫瘍の治療成績向上をめざして

臨床専門分野


悪性脳腫瘍



間脳下垂体腫瘍



頭蓋底腫瘍




研究専門分野


脳腫瘍画像解析



脳腫瘍の生物学



脳卒中画像解析


超音波の生体作用





発表論文

Link to PubMed

Link to Google Scholar

Link to Researchgate



連絡先

大阪国際がんセンター

脳神経外科

大阪市中央区大手前3−1−69

www.manabukinoshita.com

mail(at)manabukinoshita.com

 

Publication list   †: corresponding author, ‡: equal contribution

  1. 1.Ozaki T, Nakamura H, Izutsu N, Masaie H, Ishikawa J, Kinoshita M: Intracranial stenting for nilotinib treatment-associated cerebrovascular stenosis in chronic myeloid leukemia. Interv Neuroradiol. in press

  2. 2.Hirayama R, Kinoshita M, Arita H, Kagawa N, Kishima H, Hashimoto N, Fujimoto Y, Yoshimine T: Voxel-based lesion mapping of meningioma: A comprehensive lesion location mapping of 260 lesions. J Neurosurg. in press

  3. 3.Achiha T, Takagaki M, Oe H, Sakai M, Matsui H, Nakanishi K, Ozaki T, Fujimoto Y, Yoshimine T, Nakanishi K, Kinoshita M: Voxel-based lesion mapping of cryptogenic stroke in patients with advanced cancer: A detailed MRI analysis of distribution pattern. J Stroke Cerebrovasc Dis. in press

  4. 4.Nakamura T, Yamashita S, Fukumura K, Nakabayashi J, Tanaka K, Tamura K, Tateishi K, Kinoshita M, Fukushima S, Takami H, Fukuoka K, Yamazaki K, Matsushita Y, Ohno M, Miyakita Y, Shibui S, Kubo A, Shuto T, Kocialkowski S, Yamanaka S, Mukasa A, Sasayama T, Mishima K, Maehara T, Kawahara N, Nagane M, Narita Y, Mano H, Ushijima T, Ichimura K: Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma. Acta Neuropathol. 2017 Feb;133(2):321-324.

  5. 5.Illies T, Saering D, Kinoshita M, Fujinaka T, Bester M, Fiehler J, Tomiyama N, Watanabe Y: Feasibility of Quantification of Intracranial Aneurysm Pulsation with 4D CTA with Manual and Computer-Aided Post-Processing. PLoS One. 2016 Nov 23;11(11):e0166810.

  6. 6.Kinoshita M, Sakai M, Arita H, Shofuda T, Chiba Y, Kagawa N, Watanabe Y, Hashimoto N, Fujimoto Y, Yoshimine T, Nakanishi K, Kanemura Y: Introduction of high throughput magnetic resonance T2-weighted image texture analysis for WHO grade 2 and 3 gliomas. PLoS One. 2016 Oct 7;11(10):e0164268.

  7. 7.Ohnishi Y, Iwatsuki K, Shinzawa K, Ishihara M, Arita T, Kinoshita M, Fujimoto Y, Yoshimine T: Promotion of astrocytoma cell invasion by micro RNA-22 targeting of tissue inhibitor of matrix metalloproteinase-2. J Neurosurg Spine. 2017 Mar;26(3):396-403.

  8. 8.Arita H, Yamasaki K, Matsushita Y, Nakamura T, Shimowaka A, Takami H, Tanaka S, Mukasa A, Shirahata M, Shimizu S, Saito K, Kobayashi K, Higuchi F, Uzuka T, Otani R, Tamura K, Sumita K, Ohno M, Miyakita Y, Kagawa N, Hashimoto N, Hatae R, Yoshimoto K, Shinojima N, Nakamura H, Kanemura Y, Okita Y, Kinoshita M, Ishibashi K, Shofuda T, Kodama Y, Mori K, Tomogane Y, Fukai J, Fujita K, Terakawa Y, Tsuyuguchi N, Moriuchi S, Nonaka M, Suzuki H, Shibuya M, Maehara T, Saito N, Nagane M, Kawahara N, Ueki K, Yoshimine T, Miyaoka E, Nishikawa R, Komori T, Narita Y, Ichimura K: A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas. Acta Neuropathol Commun. 2016 Aug 8;4(1):79.

  9. 9.Kunitomi Y, Watanabe Y, Arisawa A, Tsukabe A, Tanaka H, Takahashi H, Nishida T, Kinoshita M, Nakamura H, Tomiyama N: Reduction of misregistration on cerebral four-dimensional computed tomography angiography images using advanced patient motion correction reconstruction. Jpn J Radiol. 2016 Sep;34(9):605-10.

  10. 10.Takagaki M, Kinoshita M, Nishino K, Nakano M, Adachi H, Ueno M, Kitamura M, Fujimoto Y, Tashiro K, Tomita Y, Imamura F, Yoshimine T: Down regulation of EGFR in metastatic brain lesion of EGFR mutated non-small cell lung cancer by tyrosine kinase inhibitor. Oncol Lett. in press

  11. 11.Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T: Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas. J Neurosurg. 2016 Nov;125(5):1136-1142.

  12. 12.Takano K, Kinoshita M, Takagaki M, Sakai M, Tateishi S, Achiha T, Hirayama R, Nishino K, Uchida J, Kumagai T, Okami J, Kawaguchi A, Hashimoto N, Nakanishi K, Imamura F, Higashiyama M, Yoshimine T: Different spatial distribution of brain metastases from lung cancer by histological subtypes and EGFR mutation status. Neuro-oncology. 2016 May;18(5):716-24.

  13. 13.Nakamura T, Tateishi K, Niwa T, Matsushita Y, Tamura K, Kinoshita M, Tanaka K, Fukushima S, Takami H, Arita H, Kubo A, Shuto T, Ohno M, Miyakita Y, Kocialkowski S, Sasayama T, Hashimoto N, Maehara T, Shibui S, Ushijima T, Kawahara N, Narita Y, Ichimura K: Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas. Neuropathol Appl Neurobiol. Apr;42(3):279-90.

  14. 14.Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T: Diagnostic and prognostic value of 11C-methionine positron emission tomography for MR non-enhancing glioma. AJNR Am J Neuroradiol. 2016 Jan;37(1):44-50.

  15. 15.Hashimoto N, Tsuboi A, Kagawa N, Chiba Y, Izumoto S, Kinoshita M, Kijima N, Oka Y, Morimoto S, Nakajima H, Morita S, Sakamoto J, Nishida S, Hosen N, Oji Y, Arita N, Yoshimine T: Wilms tumor 1-peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response. Cancer Immunol Immunother. 2015 Jun;64(6):707-16.

  16. 16.Kinoshita M, Tanaka H, Arita H, Goto Y, Oshino S, Watanabe Y, Yoshimine T, Saitoh Y: Pituitary-targeted dynamic contrast-enhanced multi-slice computed tomography for detecting magnetic resonance imaging-occult functional pituitary micro-adenoma. AJNR Am J Neuroradiol. 2015 May;36(5):904-8.

  17. 17.Kinoshita M, Taniguchi M, Takagaki M, Seike N, Hashimoto N, Yoshimine T: Development of non-tissue adherent neurosurgical patty and an ex vivo assay system for adherent characteristic evaluation. J Neurosurg. 2015 May;122(5):1180-4.

  18. 18.Illies T, Säring D, Kinoshita M, Fujinaka T, Bester M, Fiehler J, Tomiyama N, Watanabe Y: Cerebral Aneurysm Pulsation: Do Iterative Reconstruction Methods Improve Measurement Accuracy in Vivo? AJNR Am J Neuroradiol. 2014 Nov-Dec;35(11):2159-63.

  19. 19.Takano K, Kinoshita M, Hashimoto N,Tanigami H, Yoshimine T: A reminder about the trigeminocardiac reflex in surgeries at the posterior third of the flax cerebri. Interdisciplinary Neurosurgery. 2014 Sep;1(3):47-49.

  20. 20.Zhao H, Aoshi T, Kawai S, Mori Y, Fujita Y, Konishi A, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C: Olfactory is an overlooked site for the initiation of cerebral malaria. Cell Host Microbe. 2014 May 14;15(5):551-63.

  21. 21.Kinoshita M, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T: Different spatial distribution between GCB and non-GCB primary central nervous system lymphoma revealed by MR group analysis. Neuro-oncology. 2014 May;16(5):728-34.

  22. 22.Kijima N, Hosen N, Kagawa N, Hashimoto N, Kinoshita M, Oji Y, Sugiyama H, Yoshimine T: Wilms' tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis. Anticancer Res. 2014 Jan;34(1):61-7.

  23. 23.Goto Y, Kinoshita M, Oshino S, Arita H, Kitamura T, Ostuki M, Shimomura I, Yoshimine T, Saitoh Y: Gsp mutation in acromegaly and its influence on TRH-induced paradoxical GH response. Clin Endocrinol (Oxf). 2014 May;80(5):714-9.

  24. 24.Morimoto M, Yoshioka Y, Kotsuma T, Adachi K, Shiomi H, Suzuki O, Seo Y, Koizumi M, Kagawa N, Kinoshita M, Hashimoto N, Ogawa K: Hypofractionated Stereotactic Radiation Therapy in Three to Five Fractions for Vestibular Schwannoma. Jpn J Clin Oncol. 2013 Aug;43(8):805-12

  25. 25.Khoo HM, Kishima H, Kinoshita M, Goto Y, Kagawa N, Hashimoto N, Maruno M, Yoshimine T: Radiation-induced Anaplastic Ependymoma with a Remarkable Clinical Response to Temozolomide: A Case Report. Br J Neurosurg. 2013 Apr;27(2):259-61

  26. 26.Hirayama R, Fujimoto Y, Umegaki M, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T: Training for the acquisition of psychomotor skills for endoscopic endonasal surgery using a personal webcam trainer. J Neurosurg. 2013 May; 118(5):1120-6.

  27. 27.Oshino S, Nishino A, Suzuki T, Arita H, Tateishi A, Matsumoto K, Shimokawa T, Kinoshita M, Yoshimine T, Saitoh Y: Prevalence of cerebral aneurysm in patients with acromegaly. Pituitary. 2013 Jun;16(2):195-201.

  28. 28.Kinoshita M, Arita H, Goto T, Okita Y, Isohashi K, Watabe T, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T: Novel PET imaging index, 18F-fluorodeoxy glucose/11C-methionine uptake decoupling score, reflects glioma cell infiltration. J Nucl Med. 2012 Nov;53(11):1701-8.

  29. 29.Arita H, Kinoshita M, Oshino S, Kitamura T, Otsuki M, Kasayama S, Shimorura I, Yoshimine T, Saitoh Y: Biological characteristics of growth hormone-producing pituitary adenoma are different according to responsiveness to thyrotropin-releasing hormone. J Clin Endocrinol Metab. 2012 Aug;97(8):2741-7.

  30. 30.Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T: Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma. J Neurosurg. 2012 Apr;116(4):835-42.

  31. 31.Arita H, Kinoshita M, Okita Y, Hirayama R, Watabe T, Isohashi K, Kijima N, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T: Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron emission tomography. J Neuro-oncol. 2012 Apr;107(2):379-86.

  32. 32.Kijima N, Hosen N, Kagawa N, Hashimoto N, Nakano A, Fujimoto Y, Kinoshita M, Sugiyama H, Yoshimine T: CD166/Activated leukocyte cell adhesion molecule (ALCAM) is expressed on glioblastoma progenitor cells and involved in the regulation of tumor cell invasion. Neuro-oncology. 2012 Oct;14(10):1254-64.

  33. 33.Hashimoto N, Rabo CS, Okita Y, Kinoshita M, Kagawa N, Fujimoto Y, Morii E, Kishima H, Maruno M, Kato A, Yoshimine T: Skull base meningiomas grow slower compared to non-skull base ones based on volumetric and biological studies. J Neurosurg. 2012 Mar;116(3):574-80.

  34. 34.Kuroda J, Kinoshita M, Tanaka H, Nishida T, Nakamura H, Watanabe Y, Tomiyama N, Fujinaka T, Yoshimine T: Cardiac-cycle related volume change in unruptured cerebral aneurysms: a detailed volume quantification study using 4DCTA. Stroke. 2012 Jan;43(1):61-6.

  35. 35.Fujimoto Y, Hashimoto N, Kinoshita M, Miyazaki Y, Tanaka S, Yakushijin T, Takehara T, Kagawa N, Yoshimine T: Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis. Int J Clin Oncol. 2012 Jun;17(3):290-3.

  36. 36.Kinoshita M, Goto T, Arita H, Okita Y, Ishohashi K, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Saitoh Y, Hatazawa J, Hashimoto N, Yoshimine T: Imaging 18F-fluorodeoxy glucose/11C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema. J Neuro-oncol. 2012 Jan;106(2):417-25. Epub 2011 Aug 17.

  37. 37.Arita H, Kinoshita M, Kagawa N, Fujimoto Y, Kishima H, Hashimoto N, Yoshimine T: 11C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. Cancer. 2012 Mar 15;118(6):1619-27.

  38. 38.Morimoto M, Yoshioka Y, Shiomi H, Isohashi F, Konishi K, Kotsuma T, Fukuda S, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T, Koizumi M: Significance of Tumor Volume Related to Peritumoral Edema in Intracranial Meningioma Treated with Extreme Hypofractionated Stereotactic Radiation Therapy in Three to Five Fractions. Jpn J Clin Oncol. 2011 May;41(5):609-16.

  39. 39.Nishida T, Kinoshita M†‡, Tanaka H, Fujinaka T, Yoshimine T: Quantification of cerebral artery motion during the cardiac cycle. AJNR Am J Neuroradiol. 2011 Dec;32(11):E206-8.

  40. 40.Yamamoto F, Hashimoto N, Kagawa N, Okita Y, Chiba Y, Kijima N, Kinoshita M, Yoshizu K, Fujimoto Y, Hirai K, Yoshimine T. A survey of disclosure of diagnosis to patients with glioma in Japan. Int J Clin Oncol. 2011 Jun;16(3):230-7.

  41. 41.Arita H, Izumoto S, Kinoshita M, Okita Y, Hashimoto N, Fujita T, Ichimaru N, Takahara S, Yoshimine T: Posttransplant Lymphoproliferative Disease of the Central Nervous System After Kideny Transplantation: Single Center Experience Over 40 Years –Two Case Reports-. Neurol Med Chir (Tokyo). 2010;50 (12):1079-1083.

  42. 42.Rabo CS, Hashimoto N, Kagawa N, Fujita T, Hirayama R, Otsuki H, Kinoshita M, Yoshimine T: A rare case of a simultaneously detected suprasellar and intramedullary spinal cord germinoma. Brain Tumor Pathol. 2010 Oct;27(2):117-20.

  43. 43.Chiba Y, Hashimoto N, Tsuboi A, Rabo C, Oka Y, Kinoshita M, Kagawa N, Oji Y, Sugiyama H, Yoshimine T: Prognostic value of WT1 protein expression level and MIB-1 staining index as predictor of response to WT1 immunotherapy in glioblastoma patients. Brain Tumor Pathol. 2010;27(2):29-34.

  44. 44.Kinoshita M, Hashimoto N, Izumoto S, Okita Y, Kagawa N, Maruno M, Ohnishi T, Arita N, Yoshimine T: Immunohistological profiling by B-cell differentiation status of primary central nervous system lymphoma treated by high-dose methotrexate chemotherapy. J Neuro-oncol. 2010;99(1):95-101.

  45. 45.Chiba Y, Hashimoto N, Tsuboi A, Oka Y, Maruo A, Kinoshita M, Kagawa N, Oji Y, Hosen N, Nishida S, Sugiyama H, Yoshimine T: Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma. Jpn J Clin Oncol. 2010;40(5):395-403. Epub 2010 Apr 2.

  46. 46.Kinoshita M, Yoshioka Y, Okita Y, Hashimoto N, Yoshimine T: MR molecular imaging of HER-2 in a murine tumor xenograft by SPIO labeling of anti-HER-2 affibody. Contrast Media Mol Imaging. 2010;5(1):18-22.

  47. 47.Goto Y, Hashimoto N, Okita Y, Goto T, Rabo C, Hirayama H, Horikawa Y, Kinoshita M, Kagawa N, Yoshimine T: A surgically treated case of Lhermitte-Duclos disease with a precise natural history and high uptake of FDG on PET. J Neuro-oncol. 2010;97(3):445-50.

  48. 48.Okita Y, Kinoshita M, Goto T, Kagawa N, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T: 11C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma: a stereotactic image-histology comparison. Neuroimage. 2010;49(4):2977-82.

  49. 49.Kinoshita M, Goto T, Okita Y, Kagawa N, Kishima H, Hashimoto N, Yoshimine T: Diffusion tensor based tumor infiltration index cannot discriminate vasogenic edema from tumor-infiltrated edema. J Neuro-oncol. 2010;96(3):409-15.

  50. 50.Kinoshita M, Asai A, Komeda S, Yoshimura K, Takeda J, Uesaka T, Yamanouchi Y, Kanzaki H, Kawamoto K: Spontaneous Regression of a Spinal Extradural Arteriovenous Fistula After Delivery by Cesarean Section -Case Report-. Neurol Med Chir (Tokyo). 2009;49 (7):313-315.

  51. 51.Kinoshita M, Hashimoto N, Goto T, Yanagisawa T, Okita Y, Kagawa N, Kishima H, Tanaka H, Fujita N, Shimosegawa E, Hatazawa J, Yoshimine T: Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma. Neuroimage. 2009;45 (2):312-318.

  52. 52.Kinoshita M, Hashimoto N, Goto T, Kagawa N, Kishima H, Izumoto S, Tanaka H, Fujita N, Yoshimine T: Fractional anisotropy and tumor cell density of the tumor core show positive correlation in diffusion tensor magnetic resonance imaging of malignant brain tumors. Neuroimage. 2008;43 (1):29-35.

  53. 53.Kinoshita M, Izumoto S, Hashimoto N, Kishima H, Kagawa N, Hashiba T, Chiba Y, Yoshimine T: Immunohistochemical analysis of adhesion molecules and matrix metalloproteinases in malignant CNS lymphomas: A study comparing primary CNS malignant- and CNS intravascular lymphomas. Brain Tumor Pathol. 2008;25 (2):73-78.

  54. 54.Kinoshita M, Hynynen K: Key Factors That Affect Sonoporation Efficiency in in vitro Settings; The Importance of Standing Wave in Sonoporation. Biochem Biophys Res Commun. 2007 ;359(4):860-865.

  55. 55.Kinoshita M, Eguchi Y, Hynynen K: Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2. Biochem Biophys Res Commun. 2007 ;353(2):515-521.

  56. 56.Kinoshita M, McDannold N, Jolesz FA, Hynynen K: Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A. 2006 ;103(31):11719-23.

  57. 57.Kinoshita M, McDannold N, Jolesz FA, Hynynen K: Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochem Biophys Res Commun. 2006 ;340(4):1085-1090.

  58. 58.Kinoshita M, Hynynen K: Mechanism of porphyrin induced sonodynamic effect: Possible role of hyperthermia. Radiat Res. 2006;165(3):299-306.

  59. 59.Kinoshita M, Hynynen K: A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound. Biochem Biophys Res Commun. 2005 ;335(2):393-399.

  60. 60.Izumoto S, Suzuki T, Kinoshita M, Hashiba T, Kagawa N, Wada K, Fujimoto Y, Hashimoto N, Saitoh Y, Maruno M, Yoshimine T: Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: Correlation with clinical and histological features. Surg Neurol. 2005 ;63(6):520-5.

  61. 61.Kinoshita M, Hynynen K: Intracellular Delivery of Bak BH3 Peptide by Microbubble Enhanced Ultrasound. Pharm Res. 2005 ;22(5):716-720.

  62. 62.Kato A, Fujimoto Y, Hashimoto N, Taniguchi M, Kinoshita M, Hirayama A, Maruno M, Yoshimine T: Radiofrequency thermal ablation for recurrent meningioma extending extracranially. Acta Neurochir (Wien). 2005 ;147(5):543-50.

  63. 63.Kinoshita M, Yamada K, Hashimoto N, Kato A, Izumoto S, Baba T, Maruno M, Nishimura T, Yoshimine T: Fiber-tracking does not Accurately Estimate Size of Fiber Bundle in Pathological Condition: Initial Neurosurgical Experience Using Neuronavigation and Subcortical White Matter Stimulation. Neuroimage. 2005; 25(2):424-429

  64. 64.Fujimoto Y, Izumoto S, Suzuki T, Kinoshita M, Kagawa N, Wada K, Hashimoto N, Maruno M, Nakatsuji Y, Yoshimine T: Ganglioside GM3 Inhibits Proliferation and Invasion of Glioma. J Neuro-oncol. 2005;71(2):99-106.

  65. 65.Kato A, Fujimoto Y, Taniguchi M, Hashimoto N, Hirayama A, Kinoshita M, Baba T, Maruno M, Yoshimine T: Volumetric thermal devascularization of large meningiomas. J Neurosurg. 2004;101(5):779-86.

  66. 66.Kinoshita M, Izumoto S, Kagawa N, Hashimoto N, Maruno M, Yoshimine T: Long-Term Control of Recurrent Anaplastic Ependymoma with Extracranial Metastasis: Importance of Multiple Surgery and Stereotactic Radiosurgery Procedures -Case Report-. Neurol Med Chir (Tokyo). 2004;44(12):669-73.

  67. 67.Kinoshita M, Izumoto S, Oshino S, Nonaka M, Moriuchi S, Maruno M, Yoshimine T: Primary malignant lymphoma of the trigeminal region treated with rapid infusion of high-dose MTX and radiation: Case report and review of the literature. Surg Neurol. 2003;60(4):343-48.

  68. 68.Isaka T, Maruno M, Sato M, Kinoshita M, Nishida T, Kiyohara H, Yoshimine T: Brain metastasis from small-cell neuroendocrine carcinoma of the urinary bladder: a case report. Brain Tumor Pathol. 2002;19(2):117-22.

  69. 69.Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y: A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. Oncogene. 2000;19(50):5736-46.